Dolan et al  found bone density to be reduced by up to 0.9 SD in individuals with EDS compared to healthy controls, but that study did not look at individuals with hEDS specifically. Compared to age- and sex-matched controls, Gulbahar et al  reported bone density reduction of up to 0.5 SD among premenopausal women with joint hypermobility syndrome (now considered identical to hEDS). However, Carbone et al  found no difference in bone density between women with hEDS and normal controls after adjusting for height, weight, and physical activity. Multiple other clinical features including (but not limited to) sleep disturbance, fatigue, postural orthostatic tachycardia, functional gastrointestinal disorders, dysautonomia, anxiety, and depression are associated with hEDS. Some of these features were formerly included as minor diagnostic criteria for hEDS [Beighton et al 1998].
Rarer types of EDS show autosomal recessive inheritance. This means that you need two copies of the faulty gene in order to develop the condition – one from each parent. Your parents, if they each have only one faulty gene, will not have the condition.
Affected individuals are diagnosed with chronic fatigue syndrome often, fibromyalgia, depression, hypochondriasis, and/or malingering prior to recognition of joint laxity and establishment of the correct underlying diagnosis.. and/or malingering prior to recognition of joint establishment and laxity of the correct underlying diagnosis.} Tendinitis and bursitis may occur [Rombaut et al 2010b, Rombaut et al 2011a, Rombaut et al 2011b], especially greater trochanteric bursitis in those with iliotibial band syndrome. EDS does not cause inflammation directly, . and these nagging problems are likely secondary to joint instability. Temporomandibular dysfunction (“TMJ syndrome”) is relatively common [Hagberg et al 2004, De Coster et al 2005], . and can be thought of as a specific example of joint osteoarthritis and degeneration. Iliotibial band syndrome or “snapping hip” is a common symptom, often perceived by the affected individual as hip joint instability [Branson et al 2011].
If a parent has only one faulty gene, they will generally NOT have the condition. The other features of clEDS which are less common in other types of EDS are long thin fingers, ‘flat’ feet (pes planus), swollen legs, nerve compression syndromes (such as carpal tunnel syndrome), diverticular disease and wasting of the muscles in the hands and feet.
Patients P6/FIV and P5/FIV
No underlying genetic etiology has been identified in hEDS, . and thus the diagnosis is based on clinical evaluation and family history entirely. In order to better understand the different ways in which EDS can affect people, we asked our Mighty community to share some of the physical symptoms of Ehlers-Danlos syndrome that surprised them.
Therefore, this study showed the development of secondary allodynia (visceral hypersensitivity to innocuous stimulus in normal tissue that is in proximity to the site of tissue injury) in healthy subjects and non-cardiac chest pain patients. In the latter group this phenomenon longer is amplified and lasts. The resulting somatic and visceral hypersensitivity is likely due to central sensitisation. The increased excitability of spinal cord neurones appears to be the result of activation of nociceptive C fibres due to local tissue injury induced by acid infusion into the distal oesophagus. If extrapolated clinically, this study suggests that prior injury to the oesophageal mucosa may lead to the development of central sensitisation and visceral hyperalgesia in a subset of patients long after the local injury has healed.
In support of these recommendations, pantoprazole was found to provide more significant reductions in reflux symptoms and ESS scores than placebo after administration to patients with mild-moderate obstructive sleep-disordered breathing and GERD . In a published systematic review of the literature  recently, the mean prevalence of nocturnal GERD was reported to be 54%. Farup et al. , who conducted a national random-sample telephone survey, reported that 71% of subjects with GERD experienced nocturnal heartburn. In a separate study  of 1,000 individuals who experienced heartburn at least once weekly, the prevalence of nocturnal heartburn was found to be 79%; three-quarters of those with nocturnal heartburn revealed that their heartburn episodes negatively impacted their sleep.
It can be mild and is often undiagnosed probably. The main symptoms of hEDS are stretchy skin (which is not fragile but which may heal slowly) and unusually flexible joints.